The Medical College of Wisconsin has received a $1.5 million award from the National Heart, Lung and Blood Institute of the National Institutes of Health to continue their study of the molecular mechanisms of cardiovascular, pulmonary and neurodegenerative disorders.
Specifically, they are studying the mechanisms by which pro-inflammatory reactive oxygen and nitrogen molecules affect the body’s proteins and lipids in inflammatory conditions such as hardening of the arteries, asthma, diabetes, amyotrophic lateral sclerosis (ALS/Lou Gehrig’s disease), Parkinson’s and Alzheimer’s diseases. Successful completion of this study will shed new insight into the molecular changes occurring in these disorders, and may lead to development of targeted antinitration and antioxidation therapeutics.
Balaraman Kalyanaraman, Ph.D., chairman and professor of biophysics and director of the Medical College’s Free Radical Research Center, is principal investigator for this grant. Participating faculty investigators are: Jimmy Feix, Ph.D., professor of biophysics, Neil Hogg, Ph.D., professor of biophysics, Joy Joseph, Ph.D., associate professor of biophysics, Hao Zhang, Ph.D., research scientist II in biophysics, and Jacek Zielonka, Ph.D., research scientist I in biophysics.
