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May 2015
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August 2015

Programming adult stem cells to treat muscular dystrophy and more by mimicking nature

"Inducing Stem Cell Myogenesis Using NanoScript" ACS Nano

Stem cells hold great potential for addressing a variety of conditions from spinal cord injuries to cancer, but they can be difficult to control. Scientists are now reporting in the journal ACS Nano a new way to mimic the body’s natural approach to programming these cells. Using this method, they successfully directed adult stem cells to turn specifically into muscle, which could potentially help treat patients with muscular dystrophy.

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Boosting gas mileage by turning engine heat into electricity

"Thermoelectric Power Generation from Lanthanum Strontium Titanium Oxide at Room Temperature Through the Addition of Graphene" ACS Applied Materials & Interfaces

Automakers are looking for ways to improve their fleets’ average fuel efficiency, and scientists may have a new way to help them. In a report in the journal ACS Applied Materials & Interfaces, one team reports the development of a material that could convert engine heat that’s otherwise wasted into electrical energy to help keep a car running — and reduce the need for fuels. It could also have applications in aerospace, manufacturing and other sectors.

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Wisconsin doctor's invention could benefit patients, investors

By Kathleen Gallagher of the Journal Sentinel

Nearly 10 years ago, Bradley Glenn, a Green Bay doctor, saw a need for a less-invasive way to deliver chemotherapy, antibiotics and nutrients to his patients.

His solution has become the core of a small Wisconsin start-up that is aiming to deliver a big payday to investors.

Stealth Therapeutics Inc. on Tuesday will begin a trial at two Wisconsin health care organizations to determine the best potential market for the company's Invisiport, a vascular access port that is implanted under the skin in a patient's arm.

"Our goal is to use the results from the study to ramp up use of the Invisiport throughout the country," said Sam Adams, Stealth's general manager. "Future commercial success will help us to create a return for our shareholders."

In essence, the study is intended to show potential acquirers how much value the device could add to their product mix, said Ken Johnson, a director of Stealth and the managing director of Kegonsa Capital Partners. Kegonsa is a major investor in Stealth, which has raised a total of $3.35 million, Adams said.

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Elastic Gel to Heal Wounds

A team of bioengineers at Brigham and Women’s Hospital (BWH), led by Ali Khademhosseini, PhD, and Nasim Annabi, PhD, of the Biomedical Engineering Division, has developed a new protein-based gel that, when exposed to light, mimics many of the properties of elastic tissue, such as skin and blood vessels. In a paper published in Advanced Functional Materials, the research team reports on the new material’s key properties, many of which can be finely tuned, and on the results of using the material in preclinical models of wound healing.

“We are very interested in engineering strong, elastic materials from proteins because so many of the tissues within the human body are elastic. If we want to use biomaterials to regenerate those tissues, we need elasticity and flexibility,” said Annabi, a co-senior author of the study. “Our hydrogel is very flexible, made from a biocompatible polypeptide and can be activated using light.”

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