A team of bioengineers at Brigham and Women’s Hospital (BWH), led by Ali Khademhosseini, PhD, and Nasim Annabi, PhD, of the Biomedical Engineering Division, has developed a new protein-based gel that, when exposed to light, mimics many of the properties of elastic tissue, such as skin and blood vessels. In a paper published in Advanced Functional Materials, the research team reports on the new material’s key properties, many of which can be finely tuned, and on the results of using the material in preclinical models of wound healing.
“We are very interested in engineering strong, elastic materials from proteins because so many of the tissues within the human body are elastic. If we want to use biomaterials to regenerate those tissues, we need elasticity and flexibility,” said Annabi, a co-senior author of the study. “Our hydrogel is very flexible, made from a biocompatible polypeptide and can be activated using light.”